How the 3D organization of DNA controls cell identity

In researching a human disease, researchers at UPenn have discovered that the 3D organization of the genome may control cell identity.

Discover the experiments that led to this intriguing hypothesis.

This video is based on a recent publication by Shah et al. in Cell Stem Cell, May 2021 titled Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes